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Safety, infectivity, immunogenicity, and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccines in humans.

Two Salmonella typhi mutants, 541Ty (Vi+) and 543Ty (Vi-), auxotrophic for p-aminobenzoate and adenine, were evaluated as live oral vaccines. 33 volunteers ingested single doses of 10(8), 10(9), or 10(10) vaccine organisms, while four others received two 2 X 10(9) organism doses 4 d apart. No advers...

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Publicat a:J Clin Invest
Autors principals: Levine, M M, Herrington, D, Murphy, J R, Morris, J G, Losonsky, G, Tall, B, Lindberg, A A, Svenson, S, Baqar, S, Edwards, M F
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424230/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3818953/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112899
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