The compound BTB06584 is an IF(1)-dependent selective inhibitor of the mitochondrial F(1)Fo-ATPase

BACKGROUND AND PURPOSE: Ischaemia compromises mitochondrial respiration. Consequently, the mitochondrial F(1)Fo-ATPsynthase reverses and acts as a proton-pumping ATPase, so maintaining the mitochondrial membrane potential (ΔΨ(m)), while accelerating ATP depletion and cell death. Here we have looked...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ivanes, Fabrice, Faccenda, Danilo, Gatliff, Jemma, Ahmed, Ahmed A, Cocco, Stefania, Cheng, Carol Ho Ka, Allan, Emma, Russell, Claire, Duchen, Michael R, Campanella, Michelangelo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241087/
https://ncbi.nlm.nih.gov/pubmed/24641180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12638
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