Low expression of human histocompatibility leukocyte antigen-DR is associated with hypermethylation of human histocompatibility leukocyte antigen-DR alpha gene regions in B cells from patients with systemic lupus erythematosus.

The relationship between the expression of HLA-DR antigens and the HLA-DR alpha gene methylation was examined in systemic lupus erythematosus (SLE). Using permanent B cell lines, we found reduced DR expression in SLE. The low DR expression was correlated with high anti-DNA antibody titers in patient...

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Vydáno v:J Clin Invest
Hlavní autoři: Sano, H, Compton, L J, Shiomi, N, Steinberg, A D, Jackson, R A, Sasaki, T
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 1985
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424064/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2997276/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112105
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