Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model

AIMS: Population pharmacokinetic (pop PK) modelling can be used for PK assessment of drugs in breast milk. However, complex mechanistic modelling of a parent and an active metabolite using both blood and milk samples is challenging. We aimed to develop a simple predictive pop PK model for milk conce...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Tanoshima, Reo, Bournissen, Facundo Garcia, Tanigawara, Yusuke, Kristensen, Judith H, Taddio, Anna, Ilett, Kenneth F, Begg, Evan J, Wallach, Izhar, Ito, Shinya
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
Schlagworte:
Drugs in Pregnancy and Lactation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239985/
https://ncbi.nlm.nih.gov/pubmed/24773313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12409
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