Different hematologic phenotypes are associated with the leftward (-alpha 4.2) and rightward (-alpha 3.7) alpha+-thalassemia deletions.

We have compared the phenotypes of the two common deletion forms of alpha+-thalassemia by analysis of umbilical cord blood samples from Melanesia. Homozygotes for the leftward, 4.2-kilobase, deletion (-alpha 4.2) had significantly higher levels of Hb Bart's at birth than homozygotes for the rightwar...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Bowden, D K, Hill, A V, Higgs, D R, Oppenheimer, S J, Weatherall, D J, Clegg, J B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423981/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3793931/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112804
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