Role of renal metabolism and excretion in 5-nitrofuran-induced uroepithelial cancer in the rat.

5-Nitrofurans have been used in the study of chemical carcinogenesis. There is substantial evidence that N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) is deformylated to 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) in the process of FANFT-induced bladder cancer. Paradoxically, ANFT is less pot...

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Pubblicato in:	J Clin Invest
Autori principali:	Spry, L A, Zenser, T V, Cohen, S M, Davis, B B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423976/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4044826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112055
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