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Recombination–deletion between homologous cassettes in retrovirus is suppressed via a strategy of degenerate codon substitution

Transduction and expression procedures in gene therapy protocols may optimally transfer more than a single gene to correct a defect and/or transmit new functions to recipient cells or organisms. This may be accomplished by transduction with two (or more) vectors, or, more efficiently, in a single ve...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Im, Eung Jun, Bais, Anthony J, Yang, Wen, Ma, Qiangzhong, Guo, Xiuyang, Sepe, Steven M, Junghans, Richard P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239131/
https://ncbi.nlm.nih.gov/pubmed/25419532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.22
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