The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension

Although hypertension is a worldwide health issue, an incomplete understanding of its etiology has hindered our ability to treat this complex disease. Here we identify arhgap42 (also known as GRAF3) as a Rho-specific GAP expressed specifically in smooth muscle cells in mice and humans. We show that...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Bai, Xue, Lenhart, Kaitlin C., Bird, Kim E., Suen, Alisa A., Rojas, Mauricio, Kakoki, Masao, Li, Feng, Smithies, Oliver, Mack, Christopher P., Taylor, Joan M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237314/
https://ncbi.nlm.nih.gov/pubmed/24335996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3910
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