SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth

Sirtuins are NAD+ dependent deacetylases and/or ADP-ribosyl transferases active on histone and non-histone substrates. The first sirtuin was discovered as a transcriptional repressor of the mating-type-loci (Silent Information Regulator sir2) in the budding yeast, where it was shown to extend yeast...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Ma, L, Maruwge, W, Strambi, A, D'Arcy, P, Pellegrini, P, Kis, L, de Milito, A, Lain, S, Brodin, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237232/
https://ncbi.nlm.nih.gov/pubmed/25341037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.385
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