Ubiquitin-Binding Site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23

Polyglutamine repeat expansion in ataxin-3 causes neurodegeneration in the most common dominant ataxia, Spinocerebellar Ataxia Type 3 (SCA3). Since reducing levels of disease proteins improves pathology in animals, we investigated how ataxin-3 is degraded. Here we show that, unlike most proteins, at...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Blount, Jessica R., Tsou, Wei-Ling, Ristic, Gorica, Burr, Aaron A., Ouyang, Michelle, Galante, Holland, Scaglione, K. Matthew, Todi, Sokol V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237202/
https://ncbi.nlm.nih.gov/pubmed/25144244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5638
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