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Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

Previous studies show that cytotoxic activated macrophages cause inhibition of DNA synthesis, inhibition of mitochondrial respiration, and loss of intracellular iron from tumor cells. Here we examine aconitase, a citric acid cycle enzyme with a catalytically active iron-sulfur cluster, to determine...

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Udgivet i:J Clin Invest
Principais autores: Drapier, J C, Hibbs, J B
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423677/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3745439/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112642
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