Quantification and Dynamic Monitoring of EGFR T790M in Plasma Cell-Free DNA by Digital PCR for Prognosis of EGFR-TKI Treatment in Advanced NSCLC

BACKGROUND: Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI), about 50% carry the T790M mutation, but this frequency in EGFR-TKI-naïve patients and dynamic change during therapy remains un...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Zhijie, Chen, Rui, Wang, Shuhang, Zhong, Jia, Wu, Meina, Zhao, Jun, Duan, Jianchun, Zhuo, Minglei, An, Tongtong, Wang, Yuyan, Bai, Hua, Wang, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236040/
https://ncbi.nlm.nih.gov/pubmed/25405807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110780
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