Caffeine stabilizes Cdc25 independently of Rad3 in S chizosaccharomyces pombe contributing to checkpoint override

Cdc25 is required for Cdc2 dephosphorylation and is thus essential for cell cycle progression. Checkpoint activation requires dual inhibition of Cdc25 and Cdc2 in a Rad3-dependent manner. Caffeine is believed to override activation of the replication and DNA damage checkpoints by inhibiting Rad3-rel...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Alao, John P, Sjölander, Johanna J, Baar, Juliane, Özbaki-Yagan, Nejla, Kakoschky, Bianca, Sunnerhagen, Per
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235345/
https://ncbi.nlm.nih.gov/pubmed/24666325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12592
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