A Dominant-Negative Isoform of IKAROS Expands Primitive Normal Human Hematopoietic Cells

Disrupted IKAROS activity is a recurrent feature of some human leukemias, but effects on normal human hematopoietic cells are largely unknown. Here, we used lentivirally mediated expression of a dominant-negative isoform of IKAROS (IK6) to block normal IKAROS activity in primitive human cord blood c...

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Publicat a:Stem Cell Reports
Autors principals: Beer, Philip A., Knapp, David J.H.F., Kannan, Nagarajan, Miller, Paul H., Babovic, Sonja, Bulaeva, Elizabeth, Aghaeepour, Nima, Rabu, Gabrielle, Rostamirad, Shabnam, Shih, Kingsley, Wei, Lisa, Eaves, Connie J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235152/
https://ncbi.nlm.nih.gov/pubmed/25418728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.09.006
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