Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase (ADA), and in adults treated with the potent ADA inhibitor deoxycoformycin. However, the biochemical basis for deoxyadenosine toxicity...

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Bibliografske podrobnosti

izdano v:	J Clin Invest
Principais autores:	Seto, S, Carrera, C J, Kubota, M, Wasson, D B, Carson, D A
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 1985
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2579098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111710
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