Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.
Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, the rate-limiting enzyme in heme degradation to bile pigment, and has been successfully utilized to suppress hyperbilirubinemia in a variety of experimental and naturally occurring forms of jaundice in animals and man. The compou...
Enregistré dans:
| Publié dans: | J Clin Invest |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
1985
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423440/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3965510/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111689 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|