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The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML
Acute Myeloid Leukemia (AML) is an aggressive malignancy which leads to marrow failure, and ultimately death. There is a desperate need for new therapeutics for these patients. Ribonucleotide reductase (RR) is the rate limiting enzyme in DNA synthesis. Didox (3,4-Dihydroxybenzohydroxamic acid) is a...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234372/ https://ncbi.nlm.nih.gov/pubmed/25402485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112619 |
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