miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer

BACKGROUND: While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of these drugs. microRNAs have potential as diagnostic, prognostic and predictive...

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Bibliographic Details
Published in:Mol Cancer
Main Authors: Corcoran, Claire, Rani, Sweta, Breslin, Susan, Gogarty, Martina, Ghobrial, Irene M, Crown, John, O’Driscoll, Lorraine
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234346/
https://ncbi.nlm.nih.gov/pubmed/24655723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-71
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