A Phase 1 Study of (131)I-CLR1404 in Patients with Relapsed or Refractory Advanced Solid Tumors: Dosimetry, Biodistribution, Pharmacokinetics, and Safety

INTRODUCTION: (131)I-CLR1404 is a small molecule that combines a tumor-targeting moiety with a therapeutic radioisotope. The primary aim of this phase 1 study was to determine the administered radioactivity expected to deliver 400 mSv to the bone marrow. The secondary aims were to determine the phar...

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發表在:PLoS One
Main Authors: Grudzinski, Joseph J., Titz, Benjamin, Kozak, Kevin, Clarke, William, Allen, Ernest, Trembath, LisaAnn, Stabin, Michael, Marshall, John, Cho, Steve Y., Wong, Terence Z., Mortimer, Joanne, Weichert, Jamey P.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234270/
https://ncbi.nlm.nih.gov/pubmed/25402488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111652
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