Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions

BACKGROUND: The mutually exclusive pattern of the major driver oncogenes in lung cancer suggests that other mutually exclusive oncogenes exist. We performed a systematic search for tyrosine kinase (TK) fusions by screening all TKs for aberrantly high RNA expression levels of the 3′ kinase domain (KD...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Suehara, Yoshiyuki, Arcila, Maria, Wang, Lu, Hasanovic, Adnan, Ang, Daphne, Ito, Tatsuo, Kimura, Yuki, Drilon, Alexander, Guha, Udayan, Rusch, Valerie, Kris, Mark G., Zakowski, Maureen F., Rizvi, Naiyer, Khanin, Raya, Ladanyi, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234119/
https://ncbi.nlm.nih.gov/pubmed/23052255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0838
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