Recombinant alpha 1-antitrypsin Pittsburgh (Met 358----Arg) is a potent inhibitor of plasma kallikrein and activated factor XII fragment.

In normal plasma, the serine protease inhibitor alpha 1-antitrypsin (alpha 1-AT) plays little or no role in the control of plasma kallikrein or activated Factor XII fragment (Factor XIIf), this function being performed by Cl-inhibitor. Recently, an alpha 1-AT variant was described with a Met----Arg...

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Publié dans:	J Clin Invest
Auteurs principaux:	Schapira, M, Ramus, M A, Jallat, S, Carvallo, D, Courtney, M
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1986
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423402/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3484756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112347
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