Targeted transgenesis identifies G(αs) as the bottleneck in β(2)-adrenergic receptor cell signaling and physiological function in airway smooth muscle

G protein-coupled receptors are the most pervasive signaling superfamily in the body and act as receptors to endogenous agonists and drugs. For β-agonist-mediated bronchodilation, the receptor-G protein-effector network consists of the β(2)-adrenergic receptor (β(2)AR), G(s), and adenylyl cyclase, e...

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Bibliografiset tiedot
Julkaisussa:Am J Physiol Lung Cell Mol Physiol
Päätekijät: Wang, Wayne C. H., Pauer, Susan H., Smith, Dan'elle C., Dixon, Madison A., Disimile, David J., Panebra, Alfredo, An, Steven S., Camoretti-Mercado, Blanca, Liggett, Stephen B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2014
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233293/
https://ncbi.nlm.nih.gov/pubmed/25260754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00209.2014
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