Autophagy is essential for effector CD8 T cell survival and memory formation

The importance of autophagy in memory CD8 T cell differentiation in vivo is not well defined. We show here that autophagy is dynamically regulated in virus-specific CD8 T cells during acute lymphocytic choriomeningitis virus infection. Autophagy decreased in activated proliferating T cells, and was...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Xu, Xiaojin, Araki, Koichi, Li, Shuzhao, Han, Jin-Hwan, Ye, Lilin, Tan, Wendy G., Konieczny, Bogumila T., Bruinsma, Monique W., Martinez, Jennifer, Pearce, Erika L, Green, Douglas R., Jones, Dean P., Virgin, Herbert W., Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232981/
https://ncbi.nlm.nih.gov/pubmed/25362489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3025
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