The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels

ATOH8 has previously been shown to be an iron-regulated transcription factor, however its role in iron metabolism is not known. ATOH8 expression in HEK293 cells resulted in increased endogenous HAMP mRNA levels as well as HAMP promoter activity. Mutation of the E-box or SMAD response elements within...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Haematol
Main Authors: Patel, Neeta, Varghese, Joe, Masaratana, Patarabutr, Latunde-Dada, Gladys O, Jacob, Molly, Simpson, Robert J, McKie, Andrew T
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Red Cells and Iron
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232863/
https://ncbi.nlm.nih.gov/pubmed/24236640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12649
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