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Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
NF-κB is responsible for upregulating gene products that control cell survival. In this study, we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide-dependent histone deacetylase, regulates the transcriptional activity of NF-κB. SIRT1, the mammalian ortholog of the yeast SIR2 (Silencing I...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC423286/ https://ncbi.nlm.nih.gov/pubmed/15152190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600244 |
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