The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is elevated in the neuronal cell bodies before the spinal axons are cut. Prophylactic injection of cAMP, however, is useless as therapy for spinal injuries. We now show that the...

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Bibliographic Details
Main Authors: Nikulina, Elena, Tidwell, J. Lille, Dai, Hai Ning, Bregman, Barbara S., Filbin, Marie T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC423273/
https://ncbi.nlm.nih.gov/pubmed/15173585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402595101
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