Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases

Sir2 enzymes are broadly conserved from bacteria to humans and have been implicated to play roles in gene silencing, DNA repair, genome stability, longevity, metabolism, and cell physiology. These enzymes bind NAD(+) and acetyllysine within protein targets and generate lysine, 2′-O-acetyl-ADP-ribose...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zhao, Kehao, Harshaw, Robyn, Chai, Xiaomei, Marmorstein, Ronen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2004
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15150415/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401057101
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