Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

The human β-globin locus control region (LCR) is required for the maintenance of an open chromatin configuration of the locus. It interacts with the genes and the hypersensitive regions flanking the locus to form an active chromatin hub (ACH) transcribing the genes. Proper developmental control of g...

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Autori principali: Patrinos, George P., de Krom, Mariken, de Boer, Ernie, Langeveld, An, Imam, A.M. Ali, Strouboulis, John, de Laat, Wouter, Grosveld, Frank G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC423198/
https://ncbi.nlm.nih.gov/pubmed/15198986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.289704
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