Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

The human β-globin locus control region (LCR) is required for the maintenance of an open chromatin configuration of the locus. It interacts with the genes and the hypersensitive regions flanking the locus to form an active chromatin hub (ACH) transcribing the genes. Proper developmental control of g...

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Autores principales: Patrinos, George P., de Krom, Mariken, de Boer, Ernie, Langeveld, An, Imam, A.M. Ali, Strouboulis, John, de Laat, Wouter, Grosveld, Frank G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC423198/
https://ncbi.nlm.nih.gov/pubmed/15198986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.289704
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