CTCF induces histone variant incorporation, erases the H3K27me3 histone mark and opens chromatin

Insulators functionally separate active chromatin domains from inactive ones. The insulator factor, CTCF, has been found to bind to boundaries and to mediate insulator function. CTCF binding sites are depleted for the histone modification H3K27me3 and are enriched for the histone variant H3.3. In or...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Weth, Oliver, Paprotka, Christine, Günther, Katharina, Schulte, Astrid, Baierl, Manuel, Leers, Joerg, Galjart, Niels, Renkawitz, Rainer
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231773/
https://ncbi.nlm.nih.gov/pubmed/25294833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku937
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