ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain

Adenosine deaminases that act on RNA (ADARs) deaminate adenosines to inosines in double-stranded RNAs including miRNA precursors. A to I editing is widespread and required for normal life. By comparing deep sequencing data of brain miRNAs from wild-type and ADAR2 deficient mouse strains, we detect e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Vesely, Cornelia, Tauber, Stefanie, Sedlazeck, Fritz J., Tajaddod, Mansoureh, von Haeseler, Arndt, Jantsch, Michael F.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
RNA
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231736/
https://ncbi.nlm.nih.gov/pubmed/25260591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku844
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