IGF-I increases markers of osteoblastic activity and reduces bone resorption via osteoprotegerin and RANK-ligand

BACKGROUND: Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. In the present work, a model of partial IGF-I deficiency was used in order to provide insight into the mechanisms of the beneficial actio...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Guerra-Menéndez, Lucia, Sádaba, Maria C, Puche, Juan E, Lavandera, Jose L, de Castro, Luis F, de Gortázar, Arancha R, Castilla-Cortázar, Inma
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231608/
https://ncbi.nlm.nih.gov/pubmed/24161214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-271
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