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Reconstruction of large-scale regulatory networks based on perturbation graphs and transitive reduction: improved methods and their evaluation

BACKGROUND: The data-driven inference of intracellular networks is one of the key challenges of computational and systems biology. As suggested by recent works, a simple yet effective approach for reconstructing regulatory networks comprises the following two steps. First, the observed effects induc...

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Bibliografske podrobnosti
izdano v:BMC Syst Biol
Main Authors: Pinna, Andrea, Heise, Sandra, Flassig, Robert J, Fuente, Alberto de la, Klamt, Steffen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231426/
https://ncbi.nlm.nih.gov/pubmed/23924435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-7-73
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