Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells

BACKGROUND: Cholesterol plays an important role in cancer development, drug resistance and chemoimmuno-sensitivity. Statins, cholesterol lowering drugs, can induce apoptosis, but also negatively interfere with CD-20 and rituximab-mediated activity. Our goal is to identify the alternative targets tha...

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Publicado en:Exp Hematol Oncol
Autores principales: Benakanakere, Indira, Johnson, Tyler, Sleightholm, Richard, Villeda, Virgilio, Arya, Monika, Bobba, Ravi, Freter, Carl, Huang, Chunfa
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231203/
https://ncbi.nlm.nih.gov/pubmed/25401046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2162-3619-3-24
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