Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing: Correlation between Natural Evolution and On-Treatment Evolution

AIM: To evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment. METHODS: Ultra-deep pyrosequencing of HBV preCore/Core regions in 30 sequential samples (baseline [diagno...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Homs, Maria, Caballero, Andrea, Gregori, Josep, Tabernero, David, Quer, Josep, Nieto, Leonardo, Esteban, Rafael, Buti, Maria, Rodriguez-Frias, Francisco
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231103/
https://ncbi.nlm.nih.gov/pubmed/25393280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112306
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