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Poly(I:C) Induces Antiviral Immune Responses in Japanese Flounder (Paralichthys olivaceus) That Require TLR3 and MDA5 and Is Negatively Regulated by Myd88

Polyinosinic:polycytidylic acid (poly(I:C)) is a ligand of toll-like receptor (TLR) 3 that has been used as an immunostimulant in humans and mice against viral diseases based on its ability to enhance innate and adapt immunity. Antiviral effect of poly(I:C) has also been observed in teleost, however...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Zhou, Zhi-xia, Zhang, Bao-cun, Sun, Li
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231074/
https://ncbi.nlm.nih.gov/pubmed/25393122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112918
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