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Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice

Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increased in the presence of tumor. This cold-stress signi...

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Pubblicato in:Bioessays
Autori principali: Messmer, Michelle N., Kokolus, Kathleen M., Eng, Jason W.-L., Abrams, Scott I., Repasky, Elizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230712/
https://ncbi.nlm.nih.gov/pubmed/25066924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201400066
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