Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons

Amyotrophic lateral sclerosis (ALS) presents motoneuron (MN)-selective protein inclusions and axonal degeneration but the underlying mechanisms of such are unknown. Using induced pluripotent cells (iPSCs) from patients with mutation in the Cu/Zn superoxide dismutase (SOD1)gene, we show that spinal M...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Chen, Hong, Qian, Kun, Du, Zhongwei, Cao, Jingyuan, Petersen, Andrew, Liu, Huisheng, Blackbourn, Lisle W., Huang, CindyTzu-Ling, Errigo, Anthony, Yin, Yingnan, Lu, Jianfeng, Ayala, Melvin, Zhang, Su-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230530/
https://ncbi.nlm.nih.gov/pubmed/24704493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.02.004
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