Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies

INTRODUCTION: Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC). Experimental and clinical trials have shown than mTOR inhibitors have anti-epileptogenic effects in TS. D...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Liu, Joan, Reeves, Cheryl, Michalak, Zuzanna, Coppola, Antonietta, Diehl, Beate, Sisodiya, Sanjay M, Thom, Maria
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230418/
https://ncbi.nlm.nih.gov/pubmed/25005575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-71
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