Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis

INTRODUCTION: Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1(IL-1) and tumor necrosis factor alpha (TNF-α), are acutely elevated following joint injury and remain elevated for prolonged...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Furman, Bridgette D, Mangiapani, Daniel S, Zeitler, Evan, Bailey, Karsyn N, Horne, Phillip H, Huebner, Janet L, Kraus, Virginia B, Guilak, Farshid, Olson, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229982/
https://ncbi.nlm.nih.gov/pubmed/24964765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4591
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