Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy

BACKGROUND: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid α-galactosylceramide could overcome immune suppression and improve vaccination aga...

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Dades bibliogràfiques
Publicat a:Br J Cancer
Autors principals: Singh, M, Quispe-Tintaya, W, Chandra, D, Jahangir, A, Venkataswamy, M M, Ng, T W, Sharma-Kharkwal, S, Carreño, L J, Porcelli, S A, Gravekamp, C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229631/
https://ncbi.nlm.nih.gov/pubmed/25314062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.486
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