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The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

BACKGROUND: Abnormal accumulation of amyloid β-protein (Aβ) in the brain plays an important role in the pathogenesis \of Alzheimer’s disease (AD). Aβ monomers assemble into oligomers and fibrils that promote neuronal dysfunction. This assembly pathway is influenced by naturally occurring brain molec...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Ou-Yang, Ming-Hsuan, Van Nostrand, William E
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228351/
https://ncbi.nlm.nih.gov/pubmed/24188129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-134
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