Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

BACKGROUND: FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; however, the underlying mechanisms remain...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS Med
Päätekijät: Gassen, Nils C., Hartmann, Jakob, Zschocke, Jürgen, Stepan, Jens, Hafner, Kathrin, Zellner, Andreas, Kirmeier, Thomas, Kollmannsberger, Lorenz, Wagner, Klaus V., Dedic, Nina, Balsevich, Georgia, Deussing, Jan M., Kloiber, Stefan, Lucae, Susanne, Holsboer, Florian, Eder, Matthias, Uhr, Manfred, Ising, Marcus, Schmidt, Mathias V., Rein, Theo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227651/
https://ncbi.nlm.nih.gov/pubmed/25386878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001755
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