A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines**

Biocatalytic approaches to the synthesis of optically pure chiral amines, starting from simple achiral building blocks, are highly desirable because such motifs are present in a wide variety of important natural products and pharmaceutical compounds. Herein, a novel one-pot ω-transaminase (TA)/monoa...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: O'Reilly, Elaine, Iglesias, Cesar, Ghislieri, Diego, Hopwood, Jennifer, Galman, James L, Lloyd, Richard C, Turner, Nicholas J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: WILEY-VCH Verlag 2014
Onderwerpen:
Communications
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227563/
https://ncbi.nlm.nih.gov/pubmed/24478044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201309208
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