Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs

We determined the dose-dependent effects of OC99, a novel, stabilized hemoglobin-based oxygen-carrier, on hemodynamics, systemic and pulmonary artery pressures, surrogates of tissue oxygen debt (arterial lactate 7.2 ± 0.1 mM/L and arterial base excess −17.9 ± 0.5 mM/L), and tissue oxygen tension (tP...

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Detalhes bibliográficos
Publicado no:Crit Care Res Pract
Main Authors: Muir, William W., del Rio, Carlos L., Ueyama, Yukie, Youngblood, Bradley L., George, Robert S., Rausch, Carl W., Lau, Billy S. H., Hamlin, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227330/
https://ncbi.nlm.nih.gov/pubmed/25405028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/864237
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