A Functional Polymorphism in the 3'-UTR of PXR Interacts with Smoking to Increase Lung Cancer Risk in Southern and Eastern Chinese Smoker

Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. Th...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Zhang, Lisha, Qiu, Fuman, Lu, Xiaoxiao, Li, Yinyan, Fang, Wenxiang, Zhang, Lan, Zhou, Yifeng, Yang, Lei, Lu, Jiachun
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227172/
https://ncbi.nlm.nih.gov/pubmed/25268617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms151017457
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