Modulation of chemokine gradients by apheresis redirects leukocyte trafficking to different compartments during sepsis, studies in a rat model

INTRODUCTION: Prior work suggests that leukocyte trafficking is determined by local chemokine gradients between the nidus of infection and the plasma. We recently demonstrated that therapeutic apheresis can alter immune mediator concentrations in the plasma, protect against organ injury, and improve...

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Veröffentlicht in:Crit Care
Hauptverfasser: Peng, Zhi-Yong, Bishop, Jeffery V, Wen, Xiao-Yan, Elder, Michele M, Zhou, Feihu, Chuasuwan, Anan, Carter, Melinda J, Devlin, Jason E, Kaynar, A Murat, Singbartl, Kai, Pike, Francis, Parker, Robert S, Clermont, Gilles, Federspiel, William J, Kellum, John A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227131/
https://ncbi.nlm.nih.gov/pubmed/24992991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc13969
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