Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

BACKGROUND: Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter, PM(2.5)) and development of insulin resistance/Type II diabetes mellitus (Type II DM). We investigated the role of hypothalamic inflammation i...

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Veröffentlicht in:Part Fibre Toxicol
Hauptverfasser: Liu, Cuiqing, Fonken, Laura K, Wang, Aixia, Maiseyeu, Andrei, Bai, Yuntao, Wang, Tse-Yao, Maurya, Santosh, Ko, Yi-An, Periasamy, Muthu, Dvonch, Timothy, Morishita, Masako, Brook, Robert D, Harkema, Jack, Ying, Zhekang, Mukherjee, Bhramar, Sun, Qinghua, Nelson, Randy J, Rajagopalan, Sanjay
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226918/
https://ncbi.nlm.nih.gov/pubmed/25358444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-014-0053-5
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