Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

The M2 isoform of pyruvate kinase (PKM2) plays an important role in aerobic glycolysis and is a mediator of the Warburg effect in tumors. It was previously thought that tumor cells switch expression of PKM from normal tissue-expressed PKM1 to tumor-specific PKM2 via an alternative splicing mechanism...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Desai, Shruti, Ding, Minming, Wang, Bin, Lu, Zhimin, Zhao, Qi, Shaw, Kenna, Yung, W.K. Alfred, Weinstein, John N., Tan, Ming, Yao, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226677/
https://ncbi.nlm.nih.gov/pubmed/24077665
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados