Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

The M2 isoform of pyruvate kinase (PKM2) plays an important role in aerobic glycolysis and is a mediator of the Warburg effect in tumors. It was previously thought that tumor cells switch expression of PKM from normal tissue-expressed PKM1 to tumor-specific PKM2 via an alternative splicing mechanism...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Desai, Shruti, Ding, Minming, Wang, Bin, Lu, Zhimin, Zhao, Qi, Shaw, Kenna, Yung, W.K. Alfred, Weinstein, John N., Tan, Ming, Yao, Jun
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2013
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226677/
https://ncbi.nlm.nih.gov/pubmed/24077665
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