Inhibition of mTOR signaling reduces PELP1-mediated tumor growth and therapy resistance

Proline, Glutamic acid- and Leucine-rich Protein 1 (PELP1) is a proto-oncogene that modulates estrogen receptor (ER) signaling. PELP1 expression is upregulated in breast cancer, contributes to therapy resistance, and is a prognostic marker of poor survival. In a subset of breast tumors, PELP1 is pre...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Gonugunta, Vijay K., Sareddy, Gangadhara R., Krishnan, Samaya Rajeshwari, Cortez, Valerie, Roy, Sudipa Saha, Tekmal, Rajeshwar Rao, Vadlamudi, Ratna K.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226651/
https://ncbi.nlm.nih.gov/pubmed/24688046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0877
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